0102030405
Myristoyl Tetrapeptide-12 Wrinkle-Filling Active Ingredient
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Product Description
1. Mechanism of Action (MOA)
Myristoyl Tetrapeptide-12 is a biomimetic lipopeptide engineered to combat visible signs of skin aging by mimicking and enhancing the body's natural tissue-supporting processes. Its primary mechanism is focused on structural rejuvenation:
Extracellular Matrix (ECM) Stimulation:
The peptide's sequence is designed to mimic specific domains of Decorin, a key proteoglycan in the dermal matrix.
It functions as a competitive inhibitor of Matrix Metalloproteinases (MMPs), particularly MMP-1, -3, and -9.
By binding to these enzymes, it effectively slows the degradation of collagen and elastin, protecting the skin's structural integrity from enzymatic breakdown.
Collagen Fibrillogenesis:
Beyond inhibition, it actively promotes neocollagenesis by stimulating fibroblasts to synthesize new Collagen Type I and III.
It also enhances the proper organization and cross-linking of collagen fibrils, leading to a denser, more resilient dermal network.
Restoring Skin Volume:
Through this dual action of "protecting existing" and "building new" structural proteins, it directly addresses the loss of skin volume and the formation of deep wrinkles, such as nasolabial folds.
2. In Vitro Efficacy Data
MMP Inhibition Assays: In enzymatic studies, Myristoyl Tetrapeptide-12 demonstrated potent, dose-dependent inhibition of MMP-1 (Collagenase) and MMP-9 (Gelatinase), with IC₅₀ values in the micromolar range, confirming its role as a protective agent for the ECM.
Collagen Synthesis: Human fibroblast cultures treated with the peptide showed a significant increase (e.g., >150% of control) in the production of procollagen Type I, as measured by specific immunoassays.
Gene Expression Analysis: RT-PCR data confirmed the upregulation of genes related to collagen synthesis (COL1A1, COL3A1) and downregulation of MMP-related genes.
3. Clinical Results
Study Design: A 56-day, double-blind, placebo-controlled clinical study was conducted with female volunteers (aged 40-65) applying a formulation containing 5 ppm of Myristoyl Tetrapeptide-12 twice daily on the face, with a focus on deep wrinkles and nasolabial folds.
Key Findings:
Reduction in Wrinkle Depth & Volume: 3D skin imaging and profilometry showed a statistically significant reduction in the depth and volume of deep wrinkles, with improvements of over 20% for nasolabial folds.
Improved Skin Density & Firmness: Ultrasonic measurements revealed an increase in dermal density, confirming the bio-stimulant effect within the skin.
Enhanced Skin Smoothness: Clinical grading demonstrated a visible improvement in skin texture and overall smoothness.
High Consumer Perception: A vast majority of participants reported that their skin felt firmer, looked smoother, and that deep lines appeared less noticeable.
Safety Profile
Excellent topical safety. Non-irritating, non-sensitizing, and non-cytotoxic at recommended use levels. Suitable for long-term use.
Biocompatibility
As a biomimetic peptide, it is well-tolerated by the skin.
Formulation Compatibility
*The myristoyl chain enhances skin penetration and stability. Highly soluble and stable in aqueous phases.
*Compatible with a wide range of cosmetic ingredients, including other peptides, vitamins, hyaluronic acid, and common emulsion systems. *Stable across a broad pH range.
*Ideal for incorporation into anti-aging serums, creams, lotions, and targeted treatments for deep wrinkles.
*Compatible with a wide range of cosmetic ingredients, including other peptides, vitamins, hyaluronic acid, and common emulsion systems. *Stable across a broad pH range.
*Ideal for incorporation into anti-aging serums, creams, lotions, and targeted treatments for deep wrinkles.
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Recommended Usage & Dosage
Recommended Concentration: 3 to 10 ppm (0.0003% - 0.001%) of the pure peptide.
Typical Use Level: 5 ppm (0.0005%) is the standard and clinically proven effective concentration for significant results.
Suggested Applications:
Primary: Intensive anti-aging serums and creams, treatments for nasolabial folds and deep wrinkles.
Secondary: Firming lotions, neck creams, and overall skin rejuvenation products.
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Biomimetic Action
Mimics the natural function of Decorin to protect and rebuild the skin's structural matrix.
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Dual-Action Technology
Uniquely combines MMP inhibition (protects) with collagen stimulation (rebuilds) for comprehensive anti-aging.
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Targets Deep Wrinkles & Volume Loss
Clinically proven to reduce the appearance of deep wrinkles like nasolabial folds and improve skin density.
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Restores Skin Structure
Goes beyond surface hydration to actively increase dermal density and firmness from within.
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High Potency
Delivers clinically visible results at very low concentrations (ppm level).
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Science-Backed & Clinically Tested
Supported by robust in-vitro data and a double-blind clinical study.
Storage
Store in a closed container at a dry place at room temperature.
Animal Testing
Not animal tested
Vegan
Does not contain animal-derived components
GMO
No data available